Understanding Menopausal Symptoms Menopause marks the end of menstrual cycles, typically occurring between ages 45 and 55. It happens when the ovaries reduce hormone production, especially estrogen and progesterone. This hormonal shift causes symptoms that vary in intensity and duration. Common symptoms include: Hot flashes and night sweats Mood changes like irritability or anxiety Sleep problems Vaginal dryness Fatigue and low energy Weight gain or changes in metabolism